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Concentration–response relationships for hydroxylated mexiletine analogs on F1586C hNav1.4 channel mutants. The curves were constructed at 0.1 and 10 Hz frequency stimulation, and fitted with a first-order binding function (Eq. 1 in Materials and Methods). Each point is the mean ± SEM from at least three cells. The calculated IC50 values ± SE of the fit are reported in Table 2. The slope factors ranged between 0.74 and 1.11.
