Fig. 1.

11β-HSD1 deficiency worsens arthritis in mice. K/BxN arthritis was induced in Hsd11b1^−/− (white squares, white bar) and control mice (black squares, black bar) by ip injection of arthritogenic K/BxN serum, using a standard dose of 7.5 μl/g body weight on d 0 and d 2 (A) and a reduced dose of 5.6 μl/g body weight on d 0 only (B). Clinical score (based on edema and redness of carpal and hock joints) was measured over 21 d. Insets show AUC. Data are mean ± sd (n = 5/group), P < 0.05 by repeated-measures ANOVA or (for AUC) by unpaired Student's t test. *, P < 0.05.