Fig. 4.

Greater inflammation in Hsd11b1^−/− mice, but not in Hsd11b2^−/− mice, during sterile thioglycollate-induced peritonitis. Peritonitis was induced in Hsd11b1^−/− (white bars) and control mice (black bars) (A) and in Hsd11b2^−/− (white bars) and control mice (black bars) (B) by ip injection of 1 ml 3% thioglycollate. Twenty-four hours later, cells were lavaged (with 5 ml PBS) and counted. Data are mean ± sem, expressed as cells per milliliter (n = 5–8/group); *, P < 0.05 by unpaired Student's t test.