. Author manuscript; available in PMC: 2012 Jul 7.

Published in final edited form as: Chem Commun (Camb). 2011 May 26;47(25):7233–7235. doi: 10.1039/c1cc11150g

Table 2.

The effect of serum proteins on the ¹⁹F chemical shift and relaxation times.²² All samples contain 50 mM fluorinated metal chelate in either 10% of BSA in PBS or human sera at 25°C. Samples were bubbled with a flow of pure N₂ or O₂ for 10 min a t 0°C before measurement. The changes are relative to the same sample at pH7, 25°C in PBS bubbled with pure N₂ for 10 min.

Changed parameters	Chelates	10% BSA in PBS	Human sera

			Under N₂	Under O₂
Δδ (ppm)	FC-Tb³⁺	1.9	0.1	0.1
	FC-Gd³⁺	0.8	0.3	0.3
	FC-Y³⁺	0	−0.1	0
	FC	0	0	0.1

ΔT₁ (ms)	FC-Tb³⁺	−2.5	7.1	2.5
	FC-Gd³⁺	0.3	0	0.2
	FC-Y³⁺	−314	−303	−718
	FC	−219	−83	−490

ΔT₂ (ms)	FC-Tb³⁺	−31.1	−29.8	−30.9
	FC-Gd³⁺	−1.1	−0.8	−1.0
	FC-Y³⁺	−644	−569	−593
	FC	−600	−492	−487