Table 2.

Scope of the Pd-catalyzed enantioselective alkylation of cyclic vinylogous esters.^a

entry	substrate 6	R	product 7	yieldb(%)	eec(%)
1	6a	–CH3	7a	91	88
2	6b	–CH2CH3	7b	89	92
3	6c	–CH2Ph	7c	98	86
4	6d	–CH2C≡CH	7d	88	89
5	6e	–CH2CH2CH=CH2	7e	95	87
6	6f		7f	90	90
7	6g		7g	99	86
8	6h	–CH2CH2CN	7h	96	87
9	6i		7i	97	85
10	6j		7j	98	83
11	6k		7k	90	80
12	61	–F	71	94	91
13	6m	–CH2OTBDPSd	7m	66	58
14	6n		7n	75	57

^aConditions: β-ketoester 6 (1.0 equiv), Pd₂(pmdba)₃ (2.5 mol %), (S)-t-Bu-PHOX (L1, 6.25 mol %) in PhCH₃ (0.1 M) at 30 °C; pmdba = 4,4’-methoxydibenzylideneacetone.

^bIsolated yield.

^cDetermined by chiral HPLC or SFC.

^dTBDPS = tert-butyldiphenylsilyl, Ts = 4-toluenesulfonyl.