Figure 5.

Gene network characteristic of the adult renin cell. (A) Renin cell genes known to be involved in muscle contraction. Some of the 369 adult renin cell signature set of genes are shown in the center hexagons, with surrounding rectangles representing biologic processes (dark green), molecular functions (light green), and transcription factors (violet), with associated genes connected by lines. Genes involved in muscle contraction are highlighted in yellow. (B) Genes involved in calcium homeostasis are highlighted in yellow. (C) Transcription factors (SRF, E2A, IK3) and the smooth muscle phenotype. SRF candidate target genes are highlighted in yellow. See also Supplementary Table 3.