Table 1.
Patient characteristics at study entry for total cohort and according to feeding method at baseline
| All Patients | Demand Feeding | NG Tube Feeding | Gastrostomy Feeding | |
|---|---|---|---|---|
| Number of patients | 153 | 66 | 54 | 33 |
| Age at diagnosis of renal disease (months) | 0.12 (0 to 2.7) | 0.93 (0 to 5.2)c | 0.0 (0 to 1.6)a | 0.1 (0 to 2)a |
| Age at start of EF (months) | 3.1 (0.1 to 5.8) | – | 1.73 (0.1 to 5.4) | 2.2 (0.2 to 7.96) |
| Age at start of PD (months) | 5.0 (1.4 to 0.7.3) | 7 (3.2 to 14.1)b | 3.4 (0.7 to 5.9)a | 6.3 (0.9 to 9.7)b |
| Age at study entry (months) | 10.8 (7.2 to 18) | 11.8 (7.4 to 18.6) | 9.0 (7.2 to 14.4) | 10.8 (7 to 15) |
| Length SDS at birth | −0.47 (−1.79 to 0.46) | −0.47 (−1.69 to 0.33) | −0.47 (−2.58 to 0.13) | −0.14 (−1.74 to 1.06) |
| Length SDS at start of EF | −1.69 (−2.96 to −0.28) | – | −1.77 (−3.16 to −0.25) | −1.43 (−2.58 to 0.05) |
| Length SDS at start of PD | −1.69 (−3.45 to −0.19) | −1.80 (−3.14 to −0.47 | −2.05 (−4.50 to −0.08 | −1.26 (−2.76 to 0.57) |
| Length SDS at study entry | −2.44 (−3.72 to −1.30) | −2.63 (−3.91 to −1.54)c | −2.72 (−4.12 to −1.69)c | −2.06 (−3.27 to −0.88)b |
| Length SDS at study entry excluding infants on rhGH | −2.55 (−3.77 to −1.26) | −2.63 (−3.91 to −1.54)c | −2.72 (−4.12 to −1.61)c | −1.91 (−2.83 to 0.24)b |
| BMI SDS at birth | −0.58 ± 1.6 | −0.17 ± 1.48 | −0.65 ± 1.55 | −0.68 ± 1.74 |
| BMI SDS at start of EF | – | −1.14 ± 1.56 | −1.1 ± 1.37 | |
| BMI SDS at PD start | −0.66 ± 1.8 | −0.58 ± 1.58 | −0.84 ± 2.10 | −0.62 ± 1.9 |
| BMI SDS at study entry | −0.40 ± 1.53 | −0.58 ± 1.69 | −0.47 ± 1.40 | 0.11 ± 1.36 |
| n (%) oligoanuric | 83 (54) | 43 (65)c | 30 (55) | 10 (30)a |
| n (%) with comorbidities | 84 (55) | 34 (52) | 31 (57) | 19 (57) |
| n (%) automated PD | 112 (76) | 49 (74)c | 41 (76)c | 22 (96)a,b |
| PD fluid turnover (L/m2 per day) | 5.3 (3.5 to 7.9) | 4.3 (2.8 to 6.8)c | 5.3 (3.6 to 8.3) | 6.6 (5.5 to 9.6)a |
| Dialytic glucose exposure (g/kg per day) | 4.2 (2.9 to 7.1) | 3.4 (2.3 to 5.3)b,c | 4.5 (3.2 to 7.7)a | 6.6 (4.0 to 8.1)a |
| n (%) using biocompatible PD fluid | 66 (43) | 25 (38) | 27 (50) | 14 (42) |
| n (%) using amino acid PD fluid | 8 (5.3) | 3 (4.6) | 5 (9.3) | 0 (0) |
| n (%) phosphate binders | 107 (69.9) | 54 (83.1) | 34 (62.9) | 19 (57.6) |
| n (%) NaCl supplements | 56 (36.8) | 19 (29.2)c | 22 (40.7) | 15 (45.5)a |
| n (%) bicarbonate supplements | 58 (38.2) | 29 (44.6)c | 22 (40.7) | 7 (21.2)a |
| n (%) growth hormone | 6 (4.0) | 0 (0)c | 2 (3.7) | 4 (12.1)a |
| Hemoglobin (g/dl) | 10.8 ± 1.8 | 10.8 ± 1.7 | 10.8 ± 1.7 | 10.8 ± 2.0 |
| Bicarbonate (mmol/L) | 24.3 ± 4.6 | 23.2 ± 4.4 | 24.9 ± 3.8 | 25.5 ± 5.8 |
| Albumin (g/L) | 34.0 ± 7.4 | 34.0 ± 7.2 | 34.3 ± 7.5 | 33.8 ± 7.5 |
| Urea (mg/dl) | 83 ± 45 | 92 ± 37 | 72 ± 37 | 83 ± 48 |
| Calcium (mmol/L) | 2.40 ± 0.23 | 2.40 ± 0.25 | 2.40 ± 0.23 | 2.42 ± 0.22 |
| Inorganic phosphorus (mmol/L) | 1.75 ± 0.51 | 1.82 ± 0.52 | 1.66 ± 0.46 | 1.77 ± 0.56 |
| PTH (pg/ml) | 222 (85 to 529) | 178 (74 to 510) | 247 (97 to 575) | 243 (110 to 371) |
| Total Kt/V urea | 3.06 (2.32 to 3.81) | 3.0 (2.17 to 3.57) | 3.22 (2.32 to 3.94) | 2.91 (2.3 to 3.6) |
Data are given as mean ± SD, median (interquartile range), or percent of patients. EF, enteral feeding.
Superscript letters indicate significant difference between feeding modality groups: adifferent from demand feeding; bdifferent from NG tube feeding; cdifferent from gastrostomy feeding.