Figure 7.

Pedigree and genotypes of family G. (Left panel) Renal ultrasound of proposita postnatally (left top panel) and at the age of 4 years (left bottom panel). (Right top panel) Renal ultrasound of maternal grandmother at the age of 59 years. (Middle and bottom right panels) Renal ultrasound of the second-born daughter postnatally (middle right panel) and at the age of 15 months (bottom right panel). (Bottom panel) Bioinformatic predictions and multiple sequence alignments for the PKD1 variant R4138H identified on the paternal allele of both severely affected girls.