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Physiology of vitamin D in the body. It circulates as 25-hydroxyvitamin D (25D), which then gets converted in the kidney to 1,25-dihydroxyvitamin D (1,25D). The 1,25D has endocrine effects, shown at the right. 25D can also be taken up by monocytes and other cells where it is converted to 1,25D acting in an autocrine fashion to upregulate cathelicidin production.
