Figure 3. Associations between global cortical Pittsburgh compound B (PiB) retention and standardized cognitive scores in APOE ϵ4 carriers and a matched group of APOE ϵ4 noncarriers.

The trend lines indicate estimated mean cognition as a function of log-transformed PiB with orange representing APOE ϵ4 carriers (n = 97) and blue representing APOE ϵ4 noncarriers (n = 97) matched to the APOE ϵ4 carriers on age, sex, education, and PiB retention ratio. Shaded regions indicate 95% confidence intervals. The p values from the sequential analysis of variance (ANOVA) are listed for each cognitive domain.