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Depletion of cyclin-dependent kinase 1 (CDK1) protein increases cisplatin sensitivity. The OVCA cell line A2780S was transfected with a non-targeting (NT) siRNA or siRNA specific to CDK1 and evaluated for protein expression by Western blot analysis (A) and percent apoptotic nuclei in the presence of cisplatin (B). GAPDH was used as a protein loading control. Error bars indicate standard error of the mean.
