TABLE 4.
Convergent and divergent validity correlations at baseline for 614 schizoaffective subjects in two pooled international trials
| CORRELATION | SPEARMAN RANK CORRELATION N=614 | P-VALUE |
|---|---|---|
| Convergence | ||
| CGI-S-SCA positive and PANSS positive | 0.609 | <0.0001 |
| CGI-S-SCA negative and PANSS negative | 0.651 | <0.0001 |
| CGI-S-SCA depressive and total HAM-D-21* | 0.653 | <0.0001 |
| CGI-S-SCA manic and total YMRS† | 0.611 | <0.0001 |
| CGI-S-SCA overall and CGI-S-SCA positive | 0.719 | <0.0001 |
| CGI-S-SCA overall and CGI-S-SCA negative | 0.244 | <0.0001 |
| CGI-S-SCA overall and CGI-S-SCA depressive* | 0.204 | <0.0001 |
| CGI-S-SCA overall and CGI-S-SCA manic† | 0.402 | <0.0001 |
| Divergence | ||
| CGI-S-SCA positive and PANSS negative | 0.075 | 0.062 |
| CGI-S-SCA negative and PANSS positive | −0.042 | 0.302 |
| CGI-S-SCA negative and total HAM-D-21* | 0.267 | <0.0001 |
| CGI-S-SCA negative and total YMRS† | −0.256 | <0.0001 |
| CGI-S-SCA depressive and PANSS negative | 0.318 | <0.0001 |
| CGI-S-SCA positive and CGI-S-SCA negative | 0.171 | <0.0001 |
| CGI-S-SCA positive and CGI-S-SCA depressive | 0.089 | 0.073 |
| CGI-S-SCA positive and CGI-S-SCA manic | 0.255 | <0.0001 |
| CGI-S-SCA negative and CGI-S-SCA depressive | 0.400 | <0.0001 |
| CGI-S-SCA negative and CGI-S-SCA manic | −0.127 | 0.005 |
| CGI-S-SCA depressive and CGI-S-SCA manic | −0.304 | <0.0001 |
*
Baseline HAM-D-21 ≥16 (n=411)
†
Baseline YMRS ≥16 (n=488)
- CGI-S-SCA
Clinical Global Impression of Severity for Schizoaffective Disorder
- HAM-D-21
21-item Hamilton Rating Scale for Depression
- PANSS
Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale