Figure 3. Cell survival results for DT40 cells and their isogenic mutants continuously exposed to cisplatin.
(A) Survival percentage for each cell line exposed to cisplatin compared with concurrent control. (B) Survival data were log-transformed giving approximate normality. Black columns indicate significant differences analyzed by ANCOVA (p<0.01) between parental DT40 cells and mutants (BLM and XRCC2 cells). In contrast, FEN1-deficient cells showed no significant difference by ANCOVA (p>0.05). Bars: 95% confidence intervals for LC50 value for each cell line.