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Risk of bias in the included trials
| Study | Allocation sequence | Allocation concealment | Blinding | Number randomized | Loss to follow up N (%) |
|---|---|---|---|---|---|
| Kremsner 1988 | Unclear | Unclear | Unclear | 115 | 20 (17.4) |
| Kremsner 1994 | Unclear | Unclear | Unclear | 144 | 14 (9.7) |
| Metzger 1995 | Unclear | Unclear | Open | 120 | 12 (10) |
| Pukrittayakamee 2000 | Unclear | Unclear | Unclear | 204 | 43 (21) |
| Parola 2001 | Unclear | Adequate | Double | 115 | 7 (6.1) |
| McGready 2001 | Unclear | Adequate | Unclear | 131 | 2 (1.5) |
| Ramharter 2005 | Adequate | Adequate | Open | 100 | 5 (5) |
