Table 3.

Analytes significantly correlated with age in MPS IVA subjects

Analyte	p-value
Significantly higher in older patients (> 9.5 years) versus younger patients
IGF-1 (insulin-like growth factor-1)	0.010
IgA (immunoglobulin A)*	0.002
IgM (immunoglobulin M)*	0.004
Significantly higher in younger patients (< 9.5 years) versus older patients
Calcitonin	0.015
G-CSF (granulocyte colony-stimulating factor)	0.044
Growth hormone*	0.003
ICAM-1 (intracellular adhesion molecule-1)*	0.000
MMP-2 (matrix metalloproteinase-2)*‡	0.019
TNF-alpha (tumor necrosis factor alpha)*	0.000
TSH (thyroid stimulating hormone)	0.023
VCAM-1 (vascular cell adhesion molecule-1)*	0.009

* These analytes were also significantly different between high and low uKS groups (see Table 5).

‡This analyte was also significantly different between MPS IVA patients and unaffected controls (see Table 2).