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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Oct 5;54(20):7268–7279. doi: 10.1021/jm2008419

Figure 4.

Figure 4

Compound 2 interferes with LPS binding to TLR4/MD-2 (A) and MD-1 (B) as shown by native PAGE. 2 binding to MD-1 results in a band shift (B, left), whereas 2-induced sTLR4/MD-2 band shift was not observed (A, left) potentially due to a large size of sTLR4/MD-2 (87 kDa), compared to MD-1 (17 kDa).