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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Oct 5;54(20):7268–7279. doi: 10.1021/jm2008419

Table 1.

PIM-induced IL-6 production by thioglycollate-elicited macrophages.

Compound IL-6max(pg/ml) SE Structural variation
1 1456 161 PIM2, sn-2 ether, sn-1 ester
2 817 210 PIM2, sn-2 and sn-1 both ester
3 664 332 PIM2, sn-2 amide, sn-1 ester
4 1130 33 PIM2, sn-2 ester, sn-1 ether
5 275 62 AcPIM2, sn-2 ether, sn-1 ester
6 923 197 PGM2, sn-2 ether, sn-1 ester
7 143 31 PGM2, sn-2 and sn-1 both ester
8 494 161 PIM2, sn-2 and sn-1 both ether