Table 4. Two-way gene-gene interactions of MDR analysis.

Rank	Model		Training Bal. Acc. (%)	Testing Bal. Acc. (%)	P-value*	P-value#
1	IL4Ra	INSIG2	56.82	55.78	0.011	0.007
2	IL4Ra	EPHX1 exon 4	55.80	53.77	0.085	0.108
3	IL4Ra	STAT6	55.73	53.86	0.079	0.094
4	IL4Ra	GSTT1	55.58	55.58	0.018	0.010
5	IL4Ra	IL4	55.39	53.54	0.099	0.133
6	GSTP1	IL13 (rs1800925)	55.34	54.73	0.037	0.037
7	IL13 (rs848)	ADRB2 (rs1042713)	55.34	53.75	0.085	0.110
8	IL4	IL13 (rs1800925)	55.25	54.80	0.035	0.036
9	EPHX1 exon 4	IL13 (rs20541)	55.17	54.80	0.035	0.036
10	IL4Ra	GSTP1	55.00	53.61	0.093	0.127

^*Two- or Three-way interactions were validated based on 1000 permutations.

^#Two- or Three-way interactions were validated based on 1000 explicit tests.