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. 2012 Feb 15;7(2):e31119. doi: 10.1371/journal.pone.0031119

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Martín et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Morphine withdrawal increased MHPG production and NA turnover. Data represent the mean ± SEM 60 min after naloxone injection to control pellets- or morphine-treated rats. **p<0.01; ***p<0.001 vs. control pellets (placebo)+naloxone; ⁺p<0.05, ⁺⁺⁺p<0.001 vs. morphine-treated rats+saline; ^## p<0.01 vs. placebo-treated rats+saline.