Table 1. Strain-dependent expression of genes in the mouse hippocampus.
genomic locus | differentially expressed gene | |
wild type: C57BL/6J vs BALB/c | all | 588 |
all | 961 | |
dab1 KO: C57BL/6J vs BALB/c | Chromosome 1 (D1Mit215-D1Mit90) | 7 |
Chromosome 12 (D12Mit12-D12Mit18) | 40 | |
Chromosome 16 (D16Mit94-D16Mit86) | 0 |
We examined expression of mRNA transcripts by microarray between C57BL6 and BALB/c wild-type or dab1−/− mutant mice. Genes that were differentially expressed above a threshold of 1.5 fold were scored and examined for chromosomal position related to QTLs that are associated with Tau hyperphosphorylation in dab1−/− mutants (Brich et al., 2003).