Table 2. Characterization of genes that are differentially expressed between C57BL6 and BALB/c background Dab1 mutant mice and map to the Tau phosphorylation QTL on chromosome 1.

Gene Symbol	Accession number	Distance from D1Mit365 (Mb)	fold differences	Gene description
Scly	BC019879	0.83	−3.76	Putative selenocysteine lyase
Stk25	BC071218	1.49	1.86	Serine/threonine-protein kinase 25
Thap4	BC013538	1.58	2.29	THAP domain containing 4
Vps4b	BC003799	14.63	3.17	vacuolar protein sorting 4B
Clasp1	BC057312	26.26	2.39	cytoplasmic linker associated protein 1
Dbi	BC028874	27.98	−1.68	diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
Dpp10	BC067026	31.20	1.65	dipeptidyl-peptidase 10

The QTL at D1Mit365 segregates with Tau hyperphosphorylation in dab1−/− mutant mice. We identified 7 differentially expressed genes that map between markers that define the outer limits of the QTL (D1Mit215-D1Mit90). One of these, Stk25, was considered a good candidate since it encoded a serine/threonine kinase. Gene expression differences for dab1−/− mutant animals are shown for C57BL/6 versus BALB/c backgrounds (negative value indicates higher expression in BALB/c).