Figure 7. Lung Gpx3 shift from the basement membrane to the alveolar space following infection.

Gpx3 at basement membrane of blood vessels (Bv) and bronchioles (Br) was totally diffused at 5 and 7 dpi (a, b, c), but started to accumulate again at 9 dpi (d). In contrast, Gpx3 gradually increased and accumulated in the alveolar spaces (e, f, g, h). Mice were infected with sub-lethal dose of PR8 by intra-tracheal inhalation. Lung sections from uninfected mice were immunostained with the indicated antibodies and observed at ×60 magnification with confocal microscope. The scale bars represent 50 µm.