Table 1.
List of candidate genes regulated by Arx and controlling cortical interneuron migration and/or differentiation
| Gene symbol | Gene name | Human CNS disease | Mouse endophenotype |
|---|---|---|---|
| Cxcr 7 | Chemokine (C-X-C motif) receptor 7 | NA | Interneuron migration defects |
| Meis1 | Meis homeobox 1 | Restless legs syndrome | NA |
| Ppap2a | Phosphatidic acid phosphatase type 2A | NA | NA |
| Slc12a5 | Solute carrier family 12, member 5 | NA | Severe motor deficits |
| Ets2 | E26 avian leukemia oncogene 2 | May contribute to Down syndrome | NA |
| Phlda1 | Pleckstrin homology-like domain, family A, member 1 | NA | NA |
| Egr1 | Early growth response 1 | NA | Learning and memory defects |
| Igf1 | Insulin-like growth factor 1 | Growth retardation, deafness, and mental retardation | Defects in neurologic development |
| Lmo3 | LIM domain only 3 | NA | NA |
| Sema6a | Semaphorin 6A | NA | Impaired development of thalamocortical projections |
| Lgi1 | Leucine-rich repeat LGI family, member 1 | Lateral temporal epilepsy | Increased excitatory synaptic transmission |
| Alk | Anaplastic lymphoma kinase | Susceptibility to neuroblastoma | NA |
| Tgfb3 | Transforming growth factor, beta 3 | NA | NA |
| Napb | N-ethylmaleimide-sensitive factor attachment protein, beta | NA | NA |
| Hmgn3 | High mobility group nucleosomal binding domain 3 | NA | NA |
| Lmo1 | LIM domain only 1 | NA | NA |
| Ebf3 | Early B-cell factor 3 | NA | Interneuron migration defects |
| Rasgef1b | RasGEF domain family, member 1B | Candidate for the 4q21 deletion syndrome | NA |
| Slit2 | Slit homolog 2 (Drosophila) | NA | Abnormal axonal projections |
NA, not available.