Table 2.
Examples of Arx-bound and regulated genes that are enriched in migrating cortical interneurons (IN) compared to neurons in ganglionic eminences (GE) and cortical non-interneurons (non-IN).
| Gene | Arx knock-out mice | Arx-transfected N2a cells | Expression in cortical migrating interneurons | ||
|---|---|---|---|---|---|
| (Quillé et al., 2011) | (Quillé et al., 2011) | Cells and stage | FC | Reference | |
| Cxcr7 | ↓ KO subpallium (FC = 1.6, p < 0.05/Colasante et al., 2009) | No specific change | IN > GE at E13.5 and E15.5 | 2.2–2.3 | Faux et al. (2010) |
| Meis1 | No specific change | ↑ N2a cells (< 0.005) | GE > IN at E13.5 and E15.5 | 2.6–2.8 | Faux et al. (2010) |
| IN > non-IN at E13.5 | 2.6 | Batista-Brito et al. (2008) | |||
| Ppap2a | ↑ KO subpallium (FC = 1.4, p < 0.05) | ↑ N2a cells (p < 0.05) | IN > non-IN at E13.5 | 2.2 | Batista-Brito et al. (2008) |
| Slc12a5 = KCC2 | ↑ KO subpallium (FC = 1.8, p < 0.005) | ↑ N2a cells (p < 0.05) | IN > non-IN at E13.5 and E15.5 | 7.7 | Batista-Brito et al. (2008) |
| Ets2 | ↑ KO subpallium (FC = 1.8, p < 0.001) | ↑ N2a cells (p < 0.005) | IN > non-IN at E13.5 | 2.7 | Batista-Brito et al. (2008) |
| Phlda1 | ↑ KO subpallium (FC = 2.2, p < 0.05/Fulp et al., 2008) | ↑ N2a cells (p < 0.01) | IN > non-IN at E13.5 and E15.5 | 3.2-3.7 | Batista-Brito et al. (2008) |
| IN > non-IN at E14.5 | NA | Fulp et al. (2008) | |||
| Zif268 = Egr1 | ↑ KO subpallium (FC = 3.1, p < 0.05) | No specific change | IN > GE at E13.5 and E15.5 | 1.9–2.5 | Faux et al. (2010) |
| IN > non-IN at E13.5 | 6.4 | Batista-Brito et al. (2008) | |||
| Igf1 | ↑ KO subpallium (FC = 1.5-5, p < 0.001) | No specific change | IN > non-IN at E15.5 | 6.9 | Batista-Brito et al. (2008) |
| Lmo3 | ↑ KO subpallium (FC = 3.3, p < 0.001/Fulp et al., 2008/Colasante et al., 2009) | No specific change | IN > non-IN at E14.5 | 6.9 | Fulp et al. (2008) |
| SemaGa | ↑ KO subpallium (FC = 1.6, p < 0.01) | No specific change | IN > GE at E15.5 | 1.9 | Faux et al. (2010) |
| Lgi1 | No specific change | ↓ N2a cells (p < 0.005) | IN > non-IN at E13.5 and E15.5 | 2.7–26.2 | Batista-Brito et al. (2008)/ Marsh et al. (2008) |
| Alk | No specific change | ↓ N2a cells (p < 0.05) | IN > GE at E13.5 and E15.5 | 1.8–2.2 | Faux et al. (2010) |
| IN > non-IN at E13.5 and E14.5 | 2.5 | Batista-Brito et al. (2008)/ Marsh et al. (2008) | |||
| Tgfb3 | No specific change | ↓ N2a cells (p < 0.005) | IN > GE at E13.5 and E15.5 | 3.4–4.5 | Faux et al. (2010) |
| IN > non-IN at E13.5 and E15.5 | 5.3-5.5 | Batista-Brito et al. (2008) | |||
| Napb | No specific change | ↓ N2a cells (p < 0.05) | IN > GE at E15.5 | 2 | Faux et al. (2010) |
| IN > non-IN at E13.5 | 2.6-3 | Batista-Brito et al. (2008) | |||
FC, fold change; NA, not available.