Table 2.
Kinetic parameter estimates for MC in yellow perch for each tissue at each exposure dose. ke is the elimination rate constant (h−1), ku is the uptake rate constant (g−1·h−1), λ is the loss rate for the dose (h−1), elimination t0.5 is the half-life in each tissue, elimination t0.05 is the time for 95% elimination from the tissue (both elimination values calculated based on ke), exposure t0.5 is the half-life for exposure in each tissue, exposure t0.05 is the time for completion of 95% of the exposure (both exposure values calculated based on λ).
Tissue/Concentration | ke (h−1) | ke r2 | ku (g−1h−1) | λ (h−1) | ku, λ r2 | Elimination | Exposure | ||
---|---|---|---|---|---|---|---|---|---|
t0.5 (h) | t0.05 (h) | t0.5 (h) | t0.05 (h) | ||||||
5 µg–Muscle | 0.089 ± 0.058 | 0.55 | 0.00058 ± 0.00024 | 0.047 ± 0.051 | 0.41 | 7.8 | 33.5 | 14.8 | 63.7 |
20 µg–Muscle | 0.21 ± 0.07 | 0.62 | 0.00017 ± 0.000059 | 0.043 ± 0.035 | 0.44 | 3.3 | 14.5 | 16.0 | 69.2 |
5 µg–Liver | 0.066 ± 0.037 | 0.71 | 0.0019 ± 0.0006 | 0.155 ± 0.069 | 0.59 | 10.5 | 45.4 | 4.5 | 19.3 |
20 µg–Liver | 0.066 ± 0.029 | 0.81 | 0.0016 ± 0.0007 | 0.30 ± 0.15 | 0.55 | 10.5 | 45.8 | 2.3 | 9.9 |