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. 2012 Feb 15;2:272. doi: 10.1038/srep00272

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Copyright © 2012, Macmillan Publishers Limited. All rights reserved

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(a+b): Distribution of the change in charge transport Γ for pathogenic (orange bars) and all possible (cyan bars) mutations for the p16 (CDKN2A) gene with 26740 base pairs and 111 known pathogenic mutations. (c+d): Distribution of the average (logarithmic) change in charge transport 〈log Γ〉 for all pathogenic (orange bars) and all possible (cyan bars) mutations for all 162 genes. (e+f): Distribution of the global shift Λ values for all genes, showing a consistent tendency to positive values. The average (dashed) and weighted average (dash-dotted) values are indicated by vertical lines similarly to the 0 line (dotted). The grey bars denote the error of mean for . The results for the 1D and 2-leg models are displayed in panels (a,c,e) and (b,d,f), respectively. All results shown are for L = 40, data for L = 20 and 60 are similar.

Inline graphic — (a+b): Distribution of the change in charge transport Γ for pathogenic (orange bars) and all possible (cyan bars) mutations for the p16 (CDKN2A) gene with 26740 base pairs and 111 known pathogenic mutations. (c+d): Distribution of the average (logarithmic) change in charge transport 〈log Γ〉 for all pathogenic (orange bars) and all possible (cyan bars) mutations for all 162 genes. (e+f): Distribution of the global shift Λ values for all genes, showing a consistent tendency to positive values. The average (dashed) and weighted average (dash-dotted) values are indicated by vertical lines similarly to the 0 line (dotted). The grey bars denote the error of mean for . The results for the 1D and 2-leg models are displayed in panels (a,c,e) and (b,d,f), respectively. All results shown are for L = 40, data for L = 20 and 60 are similar.