Table 2. PTSD and Depression Outcome Scores at Beginning and End of Treatment.
|
Paroxetine+Naltrexone |
Paroxetine+Placebo |
Desipramine+Naltrexone |
Desipramine+Placebo |
Time |
|
|---|---|---|---|---|---|
| Mean (SE) | Mean (SE) | Mean (SE) | Mean (SE) | F, p | |
| CAPS | |||||
| Pre | 73.54 (5.007) | 69.810 (5.166) | 62.500 (5.047) | 77.833 (4.832) | 49.633, 0.00 |
| Post | 40.024 (5.53) | 36.591 (5.570) | 26.751 (5.353) | 41.392 (4.949) | — |
| Re-experience | |||||
| Pre | 18.640 (1.863) | 17.619 (1.918) | 15.909 (1.874) | 21.417 (1.794) | 22.803, 0.00 |
| Post | 9.513 (1.926) | 9.069 (2.059) | 7.295 (2.010) | 9.350 (1.842) | — |
| Avoidance | |||||
| Pre | 32.221 (2.245) | 29.667 (2.314) | 26.227 (2.261) | 31.083 (2.165) | 41.289, 0.00 |
| Post | 17.038 (2.315) | 14.459 (2.467) | 9.697 (2.408) | 18.354 (2.221) | — |
| Hyperarousal | |||||
| Pre | 22.573 (1.677) | 22.524 (1.726) | 20.364 (1.687) | 25.333 (1.615) | 30.670, 0.00 |
| Post | 13.430 (1.734) | 13.398 (1.890) | 9.811 (1.809) | 13.925 (1.658) | — |
| HAM-D | |||||
| Pre | 13.273 (1.112) | 10.950 (1.167) | 11.195 (1.132) | 13.167 (1.065) | 8.570, 0.00 |
| Post | 9.328 (1.256) | 8.238 (1.299) | 8.563 (1.201) | 8.943 (1.117) | — |
Abbreviations: CAPS, clinician administered PTSD scale; HAM-D, Hamilton depression scale; PTSD, post-traumatic stress disorder.