Figure 4.

KMO inhibition effects on neuronal differentiation. Co-treatment with IL-1β (10 ng/ml) and the KMO inhibitor Ro 61–8048 (10 μM) caused a partial reversal of the reduction of differentiation and neuronal maturation caused by the cytokine. Dcx: from −42% with IL-1β alone to −26% with IL-1β/inhibitor; MAP2: from −37% with IL-1β alone to −22% with IL-1β/inhibitor. Results are expressed as percentage change vs the corresponding vehicle treated control (n=4). Data are shown as mean±SEM, ^*p<0.05, ^**p<0.01.