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. 2011 Nov 16;37(4):1005–1012. doi: 10.1038/npp.2011.284

Figure 2.

Figure 2

A role of R7BP in the locomotor activating actions of morphine. Knockout of R7BP increases sensitivity to the locomotor activating actions of morphine. In particular, R7BPKO mice show a significant locomotor activation at a dose of 5 mg/kg (a). Wild-type animals do not show activation at this dose (p<0.001 two-way ANOVA followed by Bonferroni test). At higher doses of morphine (10 and 20 mg/kg), locomotor activation starts much earlier in R7BPKO mice compared with their wild-type controls (b, c, p<0.001, followed by Bonferroni post hoc test). Data are expressed as mean±SEM, n=5–9 per group.