Figure 3.
A role of R7BP in opiate analgesia. Knockout of R7BP does not affect paw withdrawal latencies in the hot plate test (a). R7BPKO mice show greater responses to morphine (10 and 15 mg/kg, n=10–11 per group) than their wild-type controls (b). R7BPKO mice show greater response than their wild-type controls to the analgesic actions of fentanyl (0.125 mg/kg, n=9–10 per group) in the hot plate assay (c). *p<0.05, t-test. Data are expressed as mean±SEM.