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. 2011 Nov 16;37(4):1005–1012. doi: 10.1038/npp.2011.284

Figure 5.

Figure 5

Knockout of R7BP delays tolerance to the antiallodynic effects of morphine in neuropathic pain-suffering animals. We examined the influence of R7BP in the mechanical allodynia in the SNI model of neuropathic pain. (a) The von Frey responses of R7BPWT and R7BPKO mice following 1–10 days of spared nerve injury. Both wild-type and mutant animals develop the same degree of mechanical allodynia. Morphine (3 mg/kg s.c.) produces an antiallodynic effect on both genotypes, but responses of R7BPKOs are greater than those of their WT controls (n=7–11 per group). A delay in the development of morphine tolerance is also observed in R7BP mutants (b). Data are expressed as mean±SEM, *p<0.001 two-way ANOVA, followed by the Bonferroni post hoc test.