Table 3. Multivariate Linear Regression Model: Factors Associated with Year of Publication of Trial Reports.

Factors	Slope function (β) (95% CI)	t-Score	p-Value
More subjects per trial	+0.013 (+0.006 to +0.021)	3.40	0.001
More placebo response	+0.183 (+0.067 to +0.300)	3.13	0.002
Less drug response	–0.179 (–0.288 to –0.071)	3.27	0.001
Less use of TCAs	–5.73 (–7.97 to –3.50)	3.13	0.002
More women subjects	+0.155 (+0.053 to +0.258)	3.00	0.003
Longer trials	+0.807 (+0.268 to +1.345)	2.97	0.004

Factors listed are independently and significantly associated with more recent reports among reporting-years (1983–2010) as the continuous outcome measure. Factors not associated with more recent trials included: initial depression severity rating, IMI-eq drug dose, and dropout-rate.