Fig. 4.
Effect of basolateral Cl− removal (replacement with gluconate) on basal and flow-induced net cation transport in the CCD. A: JNa increased in tubules bathed in Cl−-free perfusate as the luminal flow rate was increased from ∼1 to 5 nl·min−1·mm−1. B: removal of basolateral Cl− eliminated FIKS but not basal JK. These data are consistent with the requirement for FIKS of a basolateral Cl−-dependent transport pathway in the CCD. Means ± SE. *P < 0.05 compared with Jx at 1 nl·min−1·mm−1 in same tubules. #P < 0.05 compared with Jx in control tubules studied at same flow rate.