Fig. 4.

Chloroquine (CQ) triggers apoptotic death in malignant peripheral nerve sheath tumor (MPNST) cells. CQ (24–48 h) induced a concentration-dependent (A) decrease in number of viable cells and (B) an increase in levels of caspase-3–like activity. * P < .05 relative to untreated. (C) Levels of cleaved caspase-3 were found to be elevated concentration-dependently following CQ treatment (24 h). (D) Broad caspase inhibition by BAF (50 µM, 1 h pretreatment) attenuated CQ-induced death (24–48 h). * P < .05 relative to cells treated with CQ alone.