Table 2.

Location, likelihood of metastasis and association with MEN1 in NETs^{21 22}

Tumour	% Metastases	% MEN1	Incidence per million per year
Insulinoma	10	5	1–2
Gastrinoma*	60	25–40	1–2
Glucagonoma	50–80	10	0.1
VIPoma	40–70	5	0.1
Somatostatinoma*	50–70	45	<0.1
Non-syndromic	60	20	1–2

^*About half of cases arise in the duodenum.

MEN1, multiple endocrine neoplasia 1; NET, neuroendocrine tumour; VIPoma, vasoactive intestinal peptide-secreting tumour.