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. 2012 Feb 13;209(2):225–233. doi: 10.1084/jem.20111044

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© 2012 Gehrig et al.

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Figure 2. — IVT tRNAs are stimulatory. (A) TLR7 response of native E. coli tRNAs (open symbols) and IVTs (closed symbols) of tRNA^Tyr (squares) and tRNA^Met (circles) normalized to CpG2216 (n = 4–6; mean + SEM). (B) Comparison at 1 µg/ml of native tRNAs (closed bars) and the corresponding IVTs (open bars) of E. coli (Ec) tRNAs for Tyr, Met, Ala1, and Phe and S. cerevisiae (Sc) tRNA^Phe (n = 4–7; mean + SEM; IVT tRNA^Phe Sc, n = 2). The control consist of an RNase A digest of native tRNA^Met and its IVT. med, medium control. **, P < 0.01; ***, P < 0.001.