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. 2012 Feb 13;209(2):307–318. doi: 10.1084/jem.20111298

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© 2012 Hur et al.

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Figure 1. — XBP1-deficient mice are resistant to APAP-induced liver toxicity. (A) Mice were i.p. injected with 500 mg/kg APAP after a 16-h fast. Serum ALT levels were measured at various time points. ALT measurements were performed on animals only when they were alive. Each symbol represents one mouse. Horizontal lines represent mean values and SEM. (B) Survival of WT (n = 20) and Xbp1Δ mice (n = 16) after APAP administration. P < 0.02 (Mantel–Cox test). (C) H&E staining of liver sections. Mice were sacrificed 24 h after APAP injection. Dotted line indicates a necrotic area. Images are representative of at least five independent experiments. Bars, 0.5 mm.