Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Feb 13;209(2):307–318. doi: 10.1084/jem.20111298

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Hur et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — Effects of APAP on hepatic GSH levels and the formation of APAP-protein adducts in WT and Xbp1^LKO mice. (A) Hepatic GSH levels were measured at various time points after 500 mg/kg APAP injection. n = 3–6 mice per group. Values represent means ± SEM. (B) Mice were sacrificed at indicated time points after APAP injection. Liver lysates of WT and Xbp1^LKO mice (KO) were prepared and pooled for Western blot analysis using anti-APAP, anti-phospho-JNK, and total JNK antibodies. (C) Liver lysates from individual mice treated with APAP for 24 h or left untreated (NT) were subjected to Western blot analysis. Note that the blot was exposed to x-ray film longer than in B to increase the sensitivity.