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Induction of Cyp1a2 and Cyp2e1 mRNAs by siRNA targeting IRE1α in XBP1-deficient liver. (A) Xbp1LKO mice were injected with lipidoid-formulated siRNAs targeting IRE1α or luciferase. 8 d later, mice were sacrificed to isolate RNA and protein from the liver for qRT-PCR and Western blot analysis (B). n = 3–5 mice per group. **, P < 0.01.
