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. 2012 Feb 13;209(2):353–364. doi: 10.1084/jem.20111941

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© 2012 Xiong et al.

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Figure 4. — IgE affinity is impaired in IgG1-deficient mice. (A) WT and hMT mice were immunized with NP₁₉KLH four times. Serum was analyzed by ELISA with NP₄- and NP₂₃-coated plates. (left) NP₄/NP₂₃ ratio. (right) Absolute absorbance value. Error bars indicate SEM. Each dot represents one mouse. (B) Same sera used in A were subjected to total IgE ELISA. (C) IgG1 and IgG2a ELISA with NP₄/NP₂₃ plates. (D) Sγ1 ratio in WT and hMT mice using the Sγ1 qPCR assay. Each dot represents one animal (four animals per group). The number of Sγ1⁺ junctions in each mouse is shown in the right panel, divided by the total number of Sμ-Sε sequences. (A–D) Horizontal bars indicate the mean.