Table 1. Common human and rodent cell lines used in breast cancer animal models. Some of their particular features are noted.
Estrogen receptor | Progesterone receptor | ErbB2 receptor | Particularities | References | ||||
---|---|---|---|---|---|---|---|---|
Human breast cancer cell lines | ||||||||
BT-474 |
+ |
+ |
+ |
|
21, 116 |
|||
MCF-7 |
+ |
+ |
- |
Cell line most used |
21, 116 |
|||
MDA MB 231 |
- |
- |
- |
|
21, 116 |
|||
SKBR3 |
- |
- |
+ |
|
21, 116 |
|||
T47-D |
+ |
+ |
- |
|
21, 116 |
|||
Rat mammary tumor cell lines | ||||||||
UHKBR-01 |
+ |
+ |
- |
Same Vimentine, Desmine expression levels as T47-D |
117 |
|||
64–24 |
- |
- |
- |
Low expression of androgen receptor |
118 |
|||
Walker 256 |
- |
+ |
- |
Rare phenotypic feature particularly aggressive |
119 |
|||
RM22 | + | - | NA | Established from a mammary carcinoma chemoinduced (MNU) | 120 |