Figure 2.

Markers of muscle proteolysis and strength. (A) Quadriceps muscle mRNA expression of proteolytic genes in mice with (+) and without (-) tumors treated daily with RGZ or PBS. Some tumor-bearing mice treated with RGZ were pair-fed [RGZ-PF(+)] to the PBS(+) group. n = 5–8 mice per group. No differences between tumor groups were detected. (B) Forelimb and hindlimb grip strength (gF, grams of force) 15 d after inoculation with tumor or vehicle. Each test was done in triplicate and averaged for each mouse. n = 13–15 mice per group. No differences between tumor groups were detected.