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. 2011 Dec 1;12(11):966–977. doi: 10.4161/cbt.12.11.18136

Figure 1.

Figure 1.

Resveratrol-induced apoptosis is inhibited by U0126. (A) Cell lysate from LNCaP and C4–2 cells, treated with the indicated doses of resveratrol for 12 h in serum-free conditions, were blotted with the indicated antibodies. The two cell lines exhibited differential cleavage of PARP. (B) Nucleosome ELISA data confirm differential apoptosis in LNCaP and C4–2 cells at 2 μM resveratrol after 12 h exposure. (C) Cell lysates from C4–2 cells treated with the indicated MEK inhibitors, at the indicated doses of resveratrol, were subjected to protein gel blot. PARP cleavage is selectively inhibited by 10 μM U0126. (D) U0126 inhibition of apoptosis by resveratrol is confirmed by nucleosome ELISA at 12 h. (E) Cell lysates from C4–2 cells treated with the indicated MEK inhibitors after EGF stimulation in serum-free conditions.