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. 2011 Dec 1;12(11):997–1004. doi: 10.4161/cbt.12.11.18366

Table 1. List of 20 SNPs found by genome wide association study (GWAS) using the 500K Affymetrix single nucleotide polymorphism (SNP) chip to be associated with aggressive prostate cancer.

SNP
 p value/Bonferroni-corrected p value
 Chromosomal region
 Minor allele frequency
 Odds ratio (95% C.I.)
 Associated gene (if applicable)
1st Criteria: Bonf. p value < 0.01 with region close to known prostate cancer gene (n = 5)
rs12699509
 1.4 × 10−8/0.006
 7p21.2
 0.29
 2.7 (1.9.–3.8)
 ETV1
rs3114316
 9.2 × 10−9/0.004
 7q11.23
 0.12
 3.4 (2.2–5.2)
 KIAA1505
rs3852402
 2.9 × 10−8/0.01
 9q23.32
 0.38
 2.2 (1.7–2.9)
 FANCC
rs2226016
 3.0 × 10−8/0.01
 11p14.1
 0.34
 2.3 (1.7–3.2)
 FSHB
rs4281668 9.9 × 10−9/0.004 15q25.3 0.42 2.9 (2.0–4.1) AKAP13
2nd Criteria: Two or more SNPs in LD and Bonf. p < 0.01 (n = 9)
rs2053140
 5.7 × 10−9/0.002
 8q13.2
 0.47
 2.6 (1.8–3.7)
 DEPDC2
rs4131931
 2.8 × 10−8/0.01
  
  
  
 (8 kb apart)
rs7089868
 1.8 × 10−8/0.007
 10q23.1
 0.47
 2.8 (2.0–4.1)
 KIAA1128
rs11596082
 1.7 × 10−8/0.007
  
  
  
 (7 kb apart)
rs2351337
 1.8 × 10−8/0.007
  
  
  
 (40 kb apart)
rs11199874
 7.2 × 10−11/3.0x10−5
 10q26.12
 0.29
 2.9 (2.1–4.1)
 No description
rs10788165
 1.3 × 10−10/5.5x10−5
  
  
  
 (12 kb apart)
rs1994198
 8.2 × 10−9/0.003
 15q21.1
 0.43
 2.6 (1.8–3.7)
 No description
rs4775302 3.1 × 10−8/0.01       (13 kb apart)
3rd Criteria: Bonf. corrected p value < 10−5 (n = 6)
rs17018760
 4.0 × 10−12/1.7 × 10−6
 2p12
 0.11
 4.4 (2.8–6.9)
 CTNNA2
rs410259
 2.2 × 10−11/1.0 × 10−5
 2p22.1
 0.12
 4.0 (2.6–6.2)
 SLC8A
rs10749408
 3.2 × 10−11/1.0 × 10−5
 10q26.12
 0.34
 2.5 (1.9–3.3)
 No description
rs2429763
 2.0 × 10−11/1.0 × 10−5
 11p14.3
 0.18
 2.9 (2.1–4.0)
 No description
rs595018
 2.0 × 10−11/1.0 × 10−5
 11q12.2
 0.19
 2.9 (2.1–4.0)
 CCDC86
rs2347306 3.0 × 10−11/1.0 × 10−5 12q24.32 0.05 5.5 (3.2–9.7) No description

C.I., confidence interval.