Table 3. Crude and adjusted odds ratio based on variant genotypes. Analysis for 10q26 was based on a recessive model and for 15q21 on a dominant model. Multivariate model variables included age at biopsy, ethnicity, family history of prostate cancer, the presence of urinary voiding symptoms, prostate specific antigen (PSA) level and digital rectal exam (DRE) status.
| SNP Information |
Alternative Alleles |
Assoc. Allele |
Frequency |
Genotype |
Odds Ratio (95% CI) |
p value |
Adjusted Odds Ratio (95% C.I.) |
p value |
||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Reference | Associated | |||||||
| rs11199874 10q26 |
A/G |
G |
0.75 |
0.70 |
A/A, A/G |
G/G |
1.42 (1.2−1.6) |
3.1 × 10−8 |
1.27 (1.1−1.5) |
0.001 |
| rs10749408 10q26 |
C/T |
T |
0.70 |
0.66 |
C/C, C/T |
T/T |
1.26 (1.1−1.4) |
6.0 × 10−5 |
1.18 (1.0−1.4) |
0.02 |
| rs10788165 10q26 |
G/T |
T |
0.67 |
0.62 |
G/G, G/T |
T/T |
1.34 (1.2−1.5) |
2.6 × 10−6 |
1.29 (1.1−1.5) |
0.0005 |
| rs4775302 15q21 |
A/G |
A |
0.59 |
0.50 |
G/G |
A/G, A/A |
1.41 (1.2−1.6) |
2.4 × 10−6 |
1.31 (1.1−1.6) |
0.001 |
| rs1994198 15q21 | C/T | T | 0.55 | 0.52 | C/C | C/T, T/T | 1.34 (1.1 – 1.6) | 3.4 × 10−5 | 1.33 (1.1 – 1.6) | 0.0009 |
C.I., confidence interval.