Table 4. Distribution of patients by aggressiveness of prostate cancer using low, intermediate and high risk categories for prostate cancer (D’Amico Classification). Variant alleles based on a combination of a 3 SNP model (rs11199874, rs10749408 and rs4775302).
| Number of Variant Alleles (Frequency Distribution) |
Number of patients with NO CANCER (n = 1776) |
Number of Patients with CANCER* (n = 1663) |
||
|---|---|---|---|---|
| LOW RISK** (n = 413) Gleason Score 6, PSA < 10, AND Stage T1c | INTERMEDIATE RISK** (n = 944) Gleason Score 7, PSA 10–20, OR Stage T2a/b | HIGH RISK** (n = 306) Gleason Score 8–10, PSA > 20, OR Stage T2c | ||
| 0 (7.3%) |
154 (8.7%) |
25 (6.1%) |
55 (5.8%) |
18 (5.9%) |
| 1 (34.3%) |
669 (37.7%) |
138 (33.4%) |
293 (31.0%) |
78 (25.5%) |
| 2 (33.8%) |
584 (32.9%) |
148 (36.1%) |
330 (34.9%) |
100 (32.7%) |
| 3 (24.6%) | 369 (20.8%) | 101 (24.5%) | 267 (28.3%) | 110 (36.0%) |
*
Comparison between patients with and without cancer by the number of variant alleles (2 × 4 table): chi-square = 44.6, p < 0.0001.
**
Comparison between patients without cancer and cancer risk groups by the number of variant alleles (4 × 4 table): chi-square = 58.1, p < 0.0001. Comparison between risk groups (cases only, 3 × 4 table): chi-square = 12.6, p = 0.05.