Table 5. Comparisons of sensitivity, specificity, positive predictive value, and negative predictive value based on the combination of the risk alleles from the three SNP model among white subjects only.
| Predictor variable |
Sensitivity (%) |
Specificity (%) |
Positive predictive value (%) |
Negative predictive value (%) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any cancer | GS 7 | GS 8–10 | Any cancer | GS 7 | GS 8–10 | Any cancer | GS 7 (26.5%) |
GS 8–10 (5.6%) |
Any cancer | GS 7 (73.5%) |
GS 8–10 (94.4%) |
|
| 1 Variant allele cut-off |
94.4 |
94.5 |
95.6 |
7.9 |
7.2 |
6.9 |
49.8 |
26.9 |
5.8 |
59.5 |
78.4 |
96.3 |
| 2 Variant alleles cut-off |
62.0 |
62.0 |
70.4 |
46.6 |
43.9 |
43.1 |
52.9 |
28.5 |
6.9 |
55.9 |
76.2 |
96.1 |
| 3 Variant alleles cut-off | 29.5 | 30.7 | 37.1 | 78.2 | 76.3 | 75.1 | 56.8 | 31.9 | 8.2 | 53.4 | 75.3 | 95.2 |