Table 3.
Placebo | Zolpidem | Placebo | Zolpidem | ||||||
---|---|---|---|---|---|---|---|---|---|
Baseline phase | Baseline phase | Chronic phase | Chronic phase | Significance | |||||
Mean | (SE) | Mean | (SE) | Mean | (SE) | Mean | (SE) | ||
Sleep Period 1 | |||||||||
Initial sleep latency (min) | 12.04 | 3.72 | 8.29 | 2.42 | 12.45 | 2.28 | 8.06 | 1.46 | - |
Wake after sleep onset (min) | 1.14 | 0.43 | 2.33 | 2.05 | 5.64 | 2.37 | 0.72 | 0.41 | - |
Total sleep time (min) | 42.55 | 3.00 | 44.74 | 2.35 | 38.55 | 3.68 | 45.91 | 2.59 | - |
Sleep efficiency* | 0.78 | 0.06 | 0.82 | 0.04 | 0.69 | 0.06 | 0.84 | 0.03 | Z>P |
Stage 1 (%)* | 0.16 | 0.06 | 0.07 | 0.02 | 0.18 | 0.05 | 0.07 | 0.01 | Z<P |
Stage 2 (%)+ | 0.33 | 0.04 | 0.43 | 0.06 | 0.50 | 0.06 | 0.44 | 0.07 | 1<2 |
slow wave sleep (%) | 0.51 | 0.06 | 0.48 | 0.07 | 0.32 | 0.07 | 0.47 | 0.06 | - |
REM sleep (%) | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | - |
Sleep Period 2 | |||||||||
Initial sleep latency (min)* | 10.58 | 2.29 | 2.71 | 0.70 | 22.04 | 9.43 | 2.31 | 0.61 | Z<P |
Wake after sleep onset (min) | 28.84 | 8.15 | 26.13 | 6.80 | 32.71 | 7.64 | 35.94 | 9.56 | - |
Total sleep time (min) | 387.30 | 8.18 | 393.13 | 8.22 | 372.12 | 10.34 | 389.53 | 9.47 | - |
Sleep efficiency | 0.91 | 0.02 | 0.93 | 0.02 | 0.87 | 0.03 | 0.91 | 0.02 | - |
Stage 1 (%)* | 0.09 | 0.02 | 0.05 | 0.01 | 0.09 | 0.02 | 0.06 | 0.01 | Z<P |
Stage 2 (%)* | 0.49 | 0.02 | 0.53 | 0.03 | 0.50 | 0.02 | 0.54 | 0.02 | Z>P |
slow wave sleep (%)+ | 0.13 | 0.02 | 0.13 | 0.02 | 0.10 | 0.02 | 0.11 | 0.02 | 1>2 |
REM sleep (%) | 0.30 | 0.02 | 0.29 | 0.02 | 0.31 | 0.02 | 0.29 | 0.01 | - |
REM latency (min) | 55.29 | 10.03 | 68.77 | 11.80 | 58.30 | 9.53 | 56.40 | 10.84 | - |
Note. SE = standard error. Significance: P = Placebo, Z = Zolpidem, 1 = baseline phase, 2 = chronic phase.
Symbols:
dash (-) = not significant;
asterisk (*) = main effect of drug condition;
plus sign (+) = main effect of phase.