Table 3. Predicted location of common tumour suppressor genes and oncogenes in the devil genome.
Gene | Opossum Chromosome | Predicted Devil Chromosome | Nearest Mapped Gene | Distance from mapped gene (Mb) |
BCL2 | 3 | 1 | KDSR | 0.2 |
MYC | 3 | 1 | ENM01188 | 8 |
NF2 | 3 | 1 | OSBP2 | 2 |
APC | 6 | 1 | REEP5 | 0.07 |
MLH1 | 6 | 1 | WDR48 | 0.7 |
PTEN | 1 | 2 | MINPP1 | 0.3 |
BRCA2 | 4 | 3 | SPG20 | 5 |
RB1 | 4 | 3 | FREM2 | 8 |
MYCL1 | 4 | 3 | CCKBR | 9 |
RAD50 | 5 | 3 | KLHL1 | 2 and 9 |
BRCA1 | 2 | 4 | SOST | 2 |
ERBB2 | 2 | 4 | SOST | 6 |
TP53 | 2 | 4 | PGBD2 & C17orf101 | 6 and 10 |
NF1 | 2 | 4 | TPST1 | 4 |
Predictions of location in the normal devil genome are based homologies revealed by cross-species chromosome painting. Distance of cancer genes from mapped genes is based on the distance in opossum genome assembly. Only those cancer genes located within a 10 Mb interval either side of a mapped gene are listed.