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. 2012 Feb 16;8(2):e1002379. doi: 10.1371/journal.pcbi.1002379

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Sriram et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Peak and (B) nadir levels of the cortisol for the normal (N), PTSD (P), and depressed (D) categories, for which significant group differences are observed (p-value0.05). For depression, there is a wide range of cortisol values observed at nadir, whereas in PTSD, the range is extremely small, indicating that in depression, due to the weak negative feedback, the fluctuations are found to be enormous that resulted in a wide range of cortisol values.

Inline graphic — (A) Peak and (B) nadir levels of the cortisol for the normal (N), PTSD (P), and depressed (D) categories, for which significant group differences are observed (p-value0.05). For depression, there is a wide range of cortisol values observed at nadir, whereas in PTSD, the range is extremely small, indicating that in depression, due to the weak negative feedback, the fluctuations are found to be enormous that resulted in a wide range of cortisol values.